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Just-in-time assembly of cell-cycle protein complexes

Lars J. Jensen¹, Ulrik de Lichtenberg², Thomas S. Jensen², Søren Brunak² & Peer Bork¹

Correspondence: (Login to view email address)

1. European Molecular Biology Laboratory, Heidelberg, Germany
2. Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark

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Document Type:

Poster

Date:

Received 09 September 2008 07:21 UTC; Posted 09 September 2008

Subjects:

Molecular Cell Biology, Bioinformatics

Tags:

• cell cycle
• complexes
• degradation
• Evolution
• expression
• phosphorylation
• regulation

Abstract:

Our comparative analysis of eukaryotic cell-cycle complexes reveals that the identity of the periodically expressed subunits differs significantly between organisms and is often mirrored by changes in cell-cycle-dependent phosphorylation of the protein products. This indicates that many different solutions have evolved for just-in-time assembly of the same molecular machines.

Presented at:

15th International Conference on Intelligent Systems for Molecular Biology, 22 July 2007

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Jensen, Lars, de Lichtenberg, Ulrik, Jensen, Thomas, Brunak, Søren, and Bork, Peer. Just-in-time assembly of cell-cycle protein complexes. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2008.2273.1> (2008)

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