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Validated, Ultra Violet Spectroscopy method for the Dissolution study of Mycophenolate mofetil immediate release 500mg tablets

Surajpal P. Verma¹, Ozair Alam¹, Pooja Mullick¹, Nadeem Siddiqui¹ & Suroor A. Khan¹

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1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard

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Date:

Received 01 September 2008 11:20 UTC; Posted 03 September 2008

Subjects:

Chemistry, Pharmacology

Tags:

• pharm
• analysis
• dissolution
• immunosuppressant

Abstract:

A simple, selective and precise dissolution method was developed and validated for the Mycophenolate mofetil immediate release tablets. The method employed dissolution medium 0.1N HCl (pH1.2) and volume 900ml with USP-II apparatus (Paddle). Detection was made by measuring the absorbance on UV at the [lambda]_max 250nm. The method show the linearity in the range of conc. 5[micro]g/ml to 40[micro]g/ml with r²=0.999. The method is also validated as per International Conference of Harmonization guidelines. The method showed the specificity with standard deviation 0.00. The method is repeatable, selective and accurate for the dissolution study of Mycophenolate mofetil immediate release tablets.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Verma, Surajpal, Alam, Ozair, Mullick, Pooja, Siddiqui, Nadeem, and Khan, Suroor. Validated, Ultra Violet Spectroscopy method for the Dissolution study of Mycophenolate mofetil immediate release 500mg tablets. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.2250.1> (2008)

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