Building Block and Building Rule: Dual Descriptor Method for Biological Sequence Analysis
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- Shandong University of Technology, China
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- Document Type:
- Manuscript
- Date:
- Received 23 August 2008 17:57 UTC; Posted 26 August 2008
- Subjects:
- Biotechnology, Bioinformatics
- Abstract:
The emergence of “Systems Biology” in recent years highlights the systematic viewpoint of bio-system modeling. Building on such a background, Dual Descriptor Method, a generic methodology for biological sequence analysis is proposed. From a systematic perspective, Dual Descriptor is defined as a two element set of Composition Weight Map and Position Weight Function which aim at reflecting the composition and permutation information of a sequence. An alternate training algorithm is provided to get an optimum description of the building patterns of the sequences. In this paper, dual descriptor method has been applied to the analysis of two typical problems of molecular biology: gene identification and the prediction of protein function. Satisfactory and insightful results are achieved. Owing to the generality of this methodology, dual descriptor method has wide application perspective for many problems of pattern recognition, especially those involved in “Systems Biology”.
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Additional information
- License:
- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Ma, Bin-Guang. Building Block and Building Rule: Dual Descriptor Method for Biological Sequence Analysis. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.2223.1> (2008)
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