The likelihood that two proteins interact might depend on the proteins’ age
Correspondence: (Login to view email address)
- EMBL-Heidelberg
- Document Type:
- Manuscript
- Date:
- Received 22 January 2007 19:19 UTC; Posted 22 January 2007
- Subjects:
- Bioinformatics, Evolutionary Biology
- Abstract:
It has been previously shown [1] that S. cerevisiae proteins preferentially interact with proteins of the same estimated likely time of origin. To study this observation further, the protein interaction networks of S. cerevisiae and H. sapiens were analyzed taking into account an estimate for the age of the proteins in these species. These estimates were obtained by studying the presence and absence of putative orthologs in other eukaryotic species. In this work preliminary results are described that point to a dependence of the likelihood of protein interaction on the proteins’ age. The probability of two proteins interactions was found to be linearly dependent on the time the proteins have co-existed in the species.
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Additional information
- License:
- This document is licensed to the public under the Creative Commons Attribution 2.5 License
- How to cite this document:
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Beltrao, Pedro. The likelihood that two proteins interact might depend on the proteins’ age. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2007.22.1> (2007)
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