0 votes

Multifunctional Nanoparticles for Imaging Guided Interventions

Yousef Haik¹, Basel al-Ramadi², Bashar Issa², Shahnaz Qadri¹, Saleh Hayek¹ & Hassan Hijaze²

Correspondence: (Login to view email address)

1. University of North Carolina at Greensboro, Center for Research Excellence in Nanobiosciences
2. United Arab Emirates University

PDF (729.6 KB)

Document Type:

Manuscript

Date:

Received 14 August 2008 12:03 UTC; Posted 21 August 2008

Subjects:

Biotechnology, Cancer

Tags:

• cancer
• magnetic hyperthermia
• Nanoparticles
• nanoscience
• Bacteria

Abstract:

We describe multifunctional magnetic nanoparticles (MNPs) encapsulated in thermosensitive, drug-bearing shells and delivered to the tumor site by genetically modified and non-pathogenic strains of bacteria with known affinity to tumors for an effective and minimally invasive protocol for tumor management. The magnetic nanoparticles also serve as a non-invasive imaging contrast agent, heating agent as well as thermometry monitoring agents. We have shown an efficient tumor management on a mouse model utilizing the MNPs. Our studies showed that these novel MNPs significantly reduce the progress of tumor and prolong the animal life and function as an imaging contrast to visually monitor the tumor treatment and evolution.

Discussion

Votes:

0 votes

(Login to vote)

Comments:

0 comments

(Login to post a comment)

Share:

(Login to share with a colleague)

Additional information

License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Haik, Yousef, al-Ramadi, Basel, Issa, Bashar, Qadri, Shahnaz, Hayek, Saleh, and Hijaze, Hassan. Multifunctional Nanoparticles for Imaging Guided Interventions. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.2190.1> (2008)

Version info:

Other versions of this document in Nature Precedings

None.

Other versions of this document elsewhere on the web

None known.

Submit a new version link