FENS Forum 2008 in Geneva, Switzerland
S28: The neurobiology of choice and decision-making.
Mushroom-bodies regulate habit
formation in Drosophila
Björn Brembs
Freie Universität Berlin, Inst. Biol. Neurobiologie
bjoern@brembs.net
Monday, July 14, 2008
FENS-Forum 2008: S28 The neurobiology of choice and decision-making.
2/10
Decisions, Decisions
Spontaneous choice behavior
Monday, July 14, 2008
FENS-Forum 2008: S28 The neurobiology of choice and decision-making.
3/10
Drosophila at the Torque Meter
Spontaneous choice in a constant environment
How flies use re-afferent feedback to modulate this spontaneous
choice behavior
Monday, July 14, 2008
FENS-Forum 2008: S28 The neurobiology of choice and decision-making.
4/10
Feedback Stimuli
Fly drawing courtesy of Reinhard Wolf
Monday, July 14, 2008
FENS-Forum 2008: S28 The neurobiology of choice and decision-making.
5/10
Associative Learning
The dichotomy of operant and classical conditioning
classical
operant
Monday, July 14, 2008
FENS-Forum 2008: S28 The neurobiology of choice and decision-making.
6/10
Dissecting Operant Learning
Classical alone
Operant alone
Operant + Classical
Brembs and Plendl, Curr. Biol. (2008, in press)
Monday, July 14, 2008
FENS-Forum 2008: S28 The neurobiology of choice and decision-making.
7/10
Multiple Memory Systems
Operant and classical components interact hierarchically
Brembs & Heisenberg (2000)
classical
operant
classical
+
Monday, July 14, 2008
FENS-Forum 2008: S28 The neurobiology of choice and decision-making.
8/10
Training:
operant + classical
Test:
Operant component alone
Classical component alone
Classical + operant components
1
2
3
Isolating the Components
Brembs & Heisenberg (2000)
Monday, July 14, 2008
FENS-Forum 2008: S28 The neurobiology of choice and decision-making.
9/10
...for
keeping
classical memories
flexible
for
generalization
Mushroom-Bodies central
"classical" (fact)
"operant"
(skill)
ˇ
Mushroom-bodies mediate
inhibition of operant learning
ˇ
Mushroom-bodies enable flexible
generalization
ˇ
Mushroom-bodies delay acquisition
of stereotyped, habitual responses
Brembs (subm.)
Monday, July 14, 2008
FENS-Forum 2008: S28 The neurobiology of choice and decision-making.
10/10
Complex, Hierarchical Interactions
between multiple memory systems instead of a simple dichotomy