Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution
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- University of California, San Diego
This manuscript is a preprint. A published version is available at:
10.1016/j.bbrc.2008.08.047 (Peer Reviewed) Published in Biochemical and Biophysical Research Communications; 375(4):623-7.- Document Type:
- Manuscript
- Date:
- Received 12 August 2008 02:08 UTC; Posted 13 August 2008
- Subjects:
- Developmental Biology, Ecology, Evolutionary Biology
- Abstract:
Although, as their names imply, estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood. To elucidate the origins and evolution of ERs and ERRs, we searched for their orthologs in the recently sequenced genome of Trichoplax, the simplest known animal, and in the genomes of three lophotrochozoans: Capitella, an annelid worm, Helobdella robusta, a leech, and Lottia gigantea, a snail. BLAST searches found an ERR in Trichoplax, but no ER. BLAST searches also found ERRs in all three lophotrochozoans and invertebrate-like ERs in Capitella and Lottia, but not in Helobdella. Unexpectedly we find that the Capitella ER sequence is closest to ERβ, unlike the other invertebrate ER sequences, which are closest to ERα. Our database searches and phylogenetic analysis indicate that invertebrate ERs evolved in a lophotrochozoan and steroid-binding ERs evolved in a deuterostome.
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- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Baker, Michael. Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.2170.1> (2008)
- Version info:
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Published version:
10.1016/j.bbrc.2008.08.047 (Peer Reviewed) Published in Biochemical and Biophysical Research Communications; 375(4):623-7. -
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