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Dentate Gyrus

Allen Institute for Brain Science¹, Rachel A. Dalley¹, Lydia L. Ng¹ & Angela L. Guillozet-Bongaarts¹

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1. Allen Institute for Brain Science

PDF (14.2 MB)

Document Type:

Manuscript

Date:

Received 18 July 2008 18:16 UTC; Posted 21 July 2008

Subjects:

Genetics & Genomics, Neuroscience

Tags:

• Dentate Gyrus
• In-situ hybridization
• Allen Institute for Brain Science
• gene expression
• hippocampus
• Neuroanatomy

Abstract:

This report contains a gene expression summary of the dentate gyrus (DG), derived from the Allen Brain Atlas (ABA) in situ hybridization mouse data set. The structure’s location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the dentate gyrus were compared to the values of the macro/parent-structure, in this case the hippocampal region, for the purpose of extracting regionally selective gene expression data. The genes with the highest ranking selectivity ratios were manually curated and verified. 50 genes were then selected and compiled for expression characterization. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. Correlations between gene expression in the dentate gyrus and the rest of the brain, across all genes in the coronal dataset (~4300 genes), were derived computationally. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report.

Collection:

Allen Brain Atlas Reports

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License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

for Brain Science, Allen Institute, Dalley, Rachel, Ng, Lydia, and Guillozet-Bongaarts, Angela. Dentate Gyrus. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2008.2095.1> (2008)

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