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Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases
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- Department of Bioinformatics, Center for Genome Science, Korea
- Department of Neurology, Samsung Medical Center, Korea
- Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Korea
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- Document Type:
- Manuscript
- Date:
- Received 14 July 2008 12:21 UTC; Posted 14 July 2008
- Subjects:
- Genetics, Bioinformatics
- Abstract:
We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions and may constitute a proportion of the mechanisms by which genetic variations cause individual differences or diseases. We categorized phosphovariants into three subtypes and developed a system that predicts them. Our method can be used to screen important polymorphisms and help to identify the mechanisms of genetic diseases.
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- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Ryu, Gil-Mi, Song, Pamela, Kim, Kyu-Won, Oh, Kyung-Soo, and Kim, Jong Hun. Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.2079.1> (2008)
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