Molecular implications of prolonged aggression experience: Th, Dat1, Snca and Bdnf gene expression in the ventral tegmental area of the victorious male mice
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- Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia
- Institute of Chemical Biology and Basic Medicine SD RAS, Novosibirsk, Russia
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This manuscript is a preprint. A published version is available at:
10.1371/journal.pone.0004190 (Peer Reviewed) Published as "Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice". PLoS ONE 4(1): e4190.- Document Type:
- Manuscript
- Date:
- Received 06 July 2008 04:20 UTC; Posted 07 July 2008
- Subjects:
- Molecular Cell Biology, Neuroscience
- Abstract:
Th, Dat1, Snca and Bdnf were the genes whose mRNA levels in the ventral tegmental area of the midbrain were measured in male mice that were victorious in 20 daily agonistic interactions and in a group of such victorious mice that had later not been allowed to fight for 14 days. This experiment demonstrated increased Th, Dat1 and Snca but not Bdnf mRNA levels in the former group as compared to the controls. In the latter group, the expression of the Th and Dat1 genes was still enhanced, while the level of Snca mRNA did not differ from that in the controls. These findings suggest that positive fighting experience enhances the expression of the genes concerned with dopaminergic systems and this enhanced expression is preserved for a long time afterwards. Significant positive correlations were found between the level of aggression and Th and Snca mRNA levels in the winners.
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- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Bondar , N. , Boyarskikh, U. , Kovalenko, I., Filipenko, M., and Kudryavtseva, N. . Molecular implications of prolonged aggression experience: Th, Dat1, Snca and Bdnf gene expression in the ventral tegmental area of the victorious male mice. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.2043.1> (2008)
- Version info:
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Published version:
10.1371/journal.pone.0004190 (Peer Reviewed) Published as "Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice". PLoS ONE 4(1): e4190. -
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