Viral organization of human proteins
Correspondence: (Login to view email address)
- National Cancer Institute, National Institutes of Health
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- Document Type:
- Manuscript
- Date:
- Received 05 July 2008 15:28 UTC; Posted 09 July 2008
- Subjects:
- Microbiology, Bioinformatics
- Abstract:
A compilation of experimentally verified interactions between HIV-1 and human proteins allows insights into the intricate interplay between viral and host proteins on a large scale.We find that HIV-1 predominantly targets rich-clubs, human proteins that are not only well connected but also strongly intertwined among each other. These assemblies of proteins putatively serve as an infection gateway, allowing the virus to take control of the human host by reaching protein pathways and diversified cellular functions in a pronounced and focused way. In particular, HIV-1 utilizes its small number of proteins in a combinatorial manner, exerting a significant influence on pathways that deal with transcriptional, translational and degradation processes. Surprisingly, the small repertoire of HIV proteins also interferes loosely with many signaling and regulation pathways, suggesting that a widespread involvement in such pathways secures the control of the host cell. Such insights offer novel perspectives to investigate the progression of HIV infection and potentially can contribute to our abilities to fight this virus.
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- License:
- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Wuchty, Stefan. Viral organization of human proteins. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.2041.1> (2008)
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