Potential role of 2,2’-biphenylquinones in the carcinogenic/anti-cancer activity of dioxins
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- Thompson Rivers University
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- Document Type:
- Manuscript
- Date:
- Received 30 May 2008 03:57 UTC; Posted 31 May 2008
- Subjects:
- Cancer, Chemistry
- Abstract:
Modes of carcinogenicity for the well-known environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been investigated over the past several decades. However, the mechanisms underlying TCDD carcinogenicity are still unclear. Recent work also suggests TCDD may have anti-cancer activity. Based on established photochemical generation of reactive 2,2’-biphenylquinone intermediates from dioxins, a novel toxicological mechanism for TCDD that may be operative is proposed. 2,2’-Biphenylquinones may be obtained via biochemical activation of dioxins such as TCDD, and these intermediates may play a role in expressing both the carcinogenic and anti-cancer activities of this important contaminant class. The broader research community is encouraged to consider this potential new mechanism for dioxin toxicology in the design of future studies, the positive or negative findings from which will supplement the datasets developed by previous and current research groups.
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- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Rayne, Sierra. Potential role of 2,2’-biphenylquinones in the carcinogenic/anti-cancer activity of dioxins. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2008.1929.1> (2008)
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