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HBsAg-vectored DNA vaccines elicit concomitant protective responses to multiple CTL epitopes relevant in human disease.

Dekun Chen¹, Allan Gould¹, Michael Mather¹, Oscar Haigh¹, Melanie Barnes¹, Jacqueline Kattenbelt¹, Scott Thomson¹, & Robert R. Tindle²

Correspondence: (Login to view email address)

1. Royal Children's Hospital,
2. Royal Children's Hospital, Sir Albert Sakzewski Virus Research Centre

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Date:

Received 26 May 2008 05:03 UTC; Posted 27 May 2008

Subjects:

Biotechnology, Cancer, Immunology

Tags:

• recombinant DNA vaccine
• hepatitis B surface antigen
• cytotoxic T cell
• Infectious disease

Abstract:

Vaccines capable of controlling neoplastic and infectious diseases which depend on the cellular immune response for their resolution, have proven difficult to develop. We, and others, have previously demonstrated that the potent immunogenicity of hepatitis B surface antigen (HBsAg), the already- licensed human vaccine for hepatitis B infection, may be exploited to deliver foreign antigens for cytotoxic T-lymphocyte (CTL) induction. In this study we demonstrate that recombinant (r) HBsAg DNA delivering a CTL polyepitope appended at the C’ terminus elicits concomitant responses to multiple epitopes restricted through a diversity of MHC class I haplotypes, which are relevant in a number of human diseases. We show that the rHBsAg DNA vaccine elicits concomitant protection against neoplastic and infectious disease. These studies vindicate the use of HBsAg as a powerful vector to deliver CTL responses to foreign antigens, and have implications for a multi-disease vaccine applicable to the HLA-polymorphic human population.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Chen, Dekun, Gould, Allan, Mather, Michael, Haigh, Oscar, Barnes, Melanie, Kattenbelt, Jacqueline, Thomson, Scott, and Tindle, Robert. HBsAg-vectored DNA vaccines elicit concomitant protective responses to multiple CTL epitopes relevant in human disease.. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.1910.1> (2008)

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