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A Study on the Origin of Peroxisomes: Possibility of Actinobacteria Symbiosis

Duhita Narendra¹, Saruhashi Satoshi¹, Hamada Kazuo², Miyata Daisuke³, Horiike Tokumasa⁴, & Shinozawa Takao¹

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1. Department of Integrative Bioscience and Biomedical Engineering, Waseda University, Japan
2. Radiance Ware Co., Waseda Research Park, Honjo Saitama, Japan
3. Faculty of Commerce and Economics, Chiba University of Commerce, Japan
4. Department of Integrated Genetics, National Institute of Genetics Center, Mishima, Shizuoka, Japan

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Date:

Received 07 May 2008 05:35 UTC; Posted 07 May 2008

Subjects:

Evolution and Ecology, Genetics, Microbiology, Bioinformatics

Tags:

• peroxisome
• actinobacteria
• symbiosis
• Evolution

Abstract:

The origin of peroxisomes as having developed from the endoplasmic reticulum (ER) was proposed on the basis of the similarity between some peroxisomal proteins and ER proteins, and the localization of some peroxisomal proteins on the ER. To study the evolutionary distance between peroxisomes and ER and Prokaryotes, we carried out a phylogenetic analysis of CDC48 (cell division control 48) and its homologs, including ER-localized CDC48, CDC48 homologs in Prokaryotes and peroxisome-localized PEX1 and PEX6. A similarity search analysis of peroxisomal protein sequences to prokaryotic protein sequences using BLAST at several thresholds (E-values) was also done. We propose Actinobacteria symbiosis for the origin of peroxisomes based on the following evidence: (1) PEX1 and PEX6 are close in distance to CDC48 homologs in Actinobacteria, and these distances are closer than to ER-localized CDC48. (2) Actinobacteria proteins show the highest degree of similarity to peroxisomal proteins compared with other prokaryotes.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Narendra, Duhita, Satoshi, Saruhashi, Kazuo, Hamada, Daisuke, Miyata, Tokumasa, Horiike, and Takao, Shinozawa. A Study on the Origin of Peroxisomes: Possibility of Actinobacteria Symbiosis. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.1866.1> (2008)

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