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Experimental and theoretical study of DNA oxidation

Yuanzhi Song¹

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1. Huaiyin Teachers College, Chemistry Department

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Document Type:

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Date:

Received 14 April 2008 11:38 UTC; Posted 14 April 2008

Subjects:

Biotechnology, Chemistry

Tags:

• DNA
• electrochemistry
• oxidation

Abstract:

The electrochemical oxidation of DNA and bases at a glassy carbon electrode were investigated using cyclic and square-wave voltammetry analysis. The predicted oxidative potentials for DNA and bases using DFT method (B3LYP) are in agreement with the experimental ones.The DNA oxidation ascribes to N-protonated guanine and adenine. The calculated oxidative peaks indicate that the initial potential of DNA oxidation is around 0.432V for N-protonated guanine and 0.368V (vs.hydrogen standard electrode) at pH 7.00, and DNA as well as bases in acidity solution are more stable than those in alkalescent solution.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Song, Yuanzhi. Experimental and theoretical study of DNA oxidation. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.1797.1> (2008)

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