Requirement of RIZ1 for cancer prevention by methyl-balanced diet
Correspondence: (Login to view email address)
- The Burnham Institute
- Research Center for Alcoholic Liver & Pancreatic Diseases, Keck School of Medicine, University of Southern California
- The burnham Institute, La Jolla, CA 92037
PDF (2.3 MB)
This manuscript is a preprint. A published version is available at:
10.1371/journal.pone.0003390 (Peer Reviewed) Published in PLoS ONE 3(10): e3390. October 13, 2008.- Document Type:
- Manuscript
- Date:
- Received 27 March 2008 17:58 UTC; Posted 28 March 2008
- Subjects:
- Cancer, Genetics & Genomics
- Abstract:
The typical Western diet is not balanced in methyl nutrients that regulate the level of the methyl donor S-adenosylmethionine (SAM) and its derivative metabolite S-adenosylhomocysteine (SAH), which in turn may control the activity of certain methyltransferases. Feeding rodents with amino acid defined and methyl-imbalanced diet decreases hepatic SAM and causes liver cancers. RIZ1 (PRDM2 or KMT8) is a tumor suppressor and functions in transcriptional repression by methylating histone H3 lysine 9. Here we show that a methyl-balanced diet conferred additional survival benefits compared to a tumor-inducing methyl-imbalanced diet only in mice with wild type RIZ1 but not in mice deficient in RIZ1. While absence of RIZ1 was tumorigenic in mice fed the balanced diet, its presence did not prevent tumor formation in mice fed the imbalanced diet. Unlike most of its related enzymes, RIZ1 was upregulated by methyl-balanced diet. Methyl-balanced diet did not fully repress oncogenes such as c-Jun in the absence of RIZ1. The data identify RIZ1 as a critical target of methyl-balanced diet in cancer prevention. The molecular understanding of dietary carcinogenesis may help people make informed choices on diet, which may greatly reduce the incidence of cancer.
Discussion
- Votes:
-
4 votes
- Comments:
-
0 comments
- (Login to share with a colleague)
Additional information
- License:
- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
-
Zhou, Wenyun, Alonso, Sergio, Takai, Daisaku, Lu, Shelly, Yamamoto, Fumiichiro, Perucho, Manuel, and Huang , Shi. Requirement of RIZ1 for cancer prevention by methyl-balanced diet. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.1732.1> (2008)
- Version info:
-
Published version:
10.1371/journal.pone.0003390 (Peer Reviewed) Published in PLoS ONE 3(10): e3390. October 13, 2008. -
Other versions of this document in Nature Precedings
None.
Other versions of this document elsewhere on the web
None known.
