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A Genome-Wide Analysis Reveals Significant Overlap of Transcription and DNA Repair in Stationary Phase Yeast

Aviv de Morgan¹, Leonid Brodsky ¹, Yefim Ronin¹, Eviatar Nevo², Abraham Korol¹ & Yechezkel Kashi³

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1. University of Haifa, Department of Evolutionary Biology and Ecology
2. University of Haifa, Institute of Evolution
3. Technion, Department of Biotechnology and Food Engineering

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Document Type:

Manuscript

Date:

Received 27 January 2008 20:07 UTC; Posted 28 January 2008

Subjects:

Genetics & Genomics, Evolutionary Biology

Tags:

• DNA repair
• stationary phase
• transcription
• yeast

Abstract:

The association between transcription and DNA repair is acknowledged as a player in the generation of mutations in a non-random fashion in prokaryotes and eukaryotes. Previous studies demonstrated that the transcription complex is capable of directing DNA repair to sites of transcription. This process is especially important to growth-arrested cells, in which many DNA repair capacities are diminished; it may also lead to mutations preferentially in transcribed genes. Using microarray analysis of growth-arrested yeast cultures, we demonstrated on a genomic scale, the co-localization of a DNA-turnover marker, indicative of DNA-repair-associated DNA synthesis, with genes persistently transcribed during stationary phase. This may serve as a clue regarding the non-random manner in which non-dividing cells may potentially mutate in the absence of replication, solely as a result of their inherent, transcriptional stress response.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

de Morgan, Aviv, Brodsky , Leonid , Ronin, Yefim, Nevo, Eviatar, Korol, Abraham, and Kashi, Yechezkel. A Genome-Wide Analysis Reveals Significant Overlap of Transcription and DNA Repair in Stationary Phase Yeast. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.1543.1> (2008)

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