0 votes

COX inhibition: Catalepsy and Striatum Dopaminergic-GABAergic-Glutamatergic Neurotransmission

Hadi Fathi-Moghaddam¹, Mehdi Shafiee Ardestani², Meysam Shafiee Ardestani³, Davood Barzegar-Pourshuraki⁴, Amin Gravand⁴, Latifeh Navidpour², Hojat Ebrahiminik⁵ & Abbas Shafiee²

Correspondence: (Login to view email address)

1. Department of Physiology and Physiology Research Center, JUMS, Ahwaz, Iran
2. Department of Medicinal Chemistry and Radiopharmacy, TUMS, Iran
3. Department of Paleomicrobiology, Tehran University of Sciences, Iran
4. Department of Pharmaceutics, JUMS, Ahwaz, Iran
5. Department of Radiology, Amir-Alam Hospital, TUMS, Iran

PDF (174.2 KB)

Document Type:

Manuscript

Date:

Received 01 January 2008 18:05 UTC; Posted 09 January 2008

Subjects:

Neuroscience, Pharmacology

Tags:

• Parkinson
• s
• disease"
• Striatal
• Neurotransmission
• COX
• Catalepsy

Abstract:

Selective COX-2 and COX-1 inhibitors were administered (i.p. acutely) to normal and parkinsonian rats, followed by the analysis of the striatal dopamine, GABA and glutamate concentrations using the microdialysis technique, simultaneously, the catalepsy of animals was evaluated. Selective COX-2 inhibition showed improving effects on the catalepsy followed by decreasing the striatum glutamatergic-GABAergic and enhancing the dopaminergic neurotransmission. Nonetheless COX inhibition had no significant improving effects on damaged Substantia Nigra Pars Compacta (SNc) neurons.

Discussion

Votes:

0 votes

(Login to vote)

Comments:

1 comment

Mehdi Shafiee Ardestani on 05 April 2009 07:12 UTC

Dear readerships:
Few parts of this un-revised pre-print have been peer-reviewed by the experts in the field and published in Journal of Basic and Clinical Pharmacology and Toxicology
Fathi Moghaddam, Hadi; Ardestani, Mehdi Shafiee; Saffari, Mostafa; Navidpour, Latifeh; Shafiee, Abbas; Rahmim, Arman:Dopaminergic but Not Glutamatergic Neurotransmission Is Increased in the Striatum after Selective Cyclooxygenase-2 Inhibition in Normal and Hemiparkinsonian Rats.Volume 103, Number 4, October 2008 , pp. 293-296(4).
This comment was sent from the authors to dissolve any un-wanted Suspicions to the document.
Best regards
The authors

(Login to post a comment)

Share:

(Login to share with a colleague)

Additional information

License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Fathi-Moghaddam, Hadi, Shafiee Ardestani, Mehdi, Shafiee Ardestani, Meysam, Barzegar-Pourshuraki, Davood, Gravand, Amin, Navidpour, Latifeh, Ebrahiminik, Hojat, and Shafiee, Abbas. COX inhibition: Catalepsy and Striatum Dopaminergic-GABAergic-Glutamatergic Neurotransmission. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.1481.1> (2008)

Version info:

Published version:

10.1111/j.1742-7843.2008.00295.x (Peer Reviewed) Parts of this un-revised pre-print have been peer-reviewed and published as: Fathi Moghaddam, Hadi; Ardestani, Mehdi Shafiee; Saffari, Mostafa; Navidpour, Latifeh; Shafiee, Abbas; Rahmim, Arman:Dopaminergic but Not Glutamatergic Neurotransmission Is Increased in the Striatum after Selective Cyclooxygenase-2 Inhibition in Normal and Hemiparkinsonian Rats. Journal of Basic and Clinical Pharmacology and Toxicology 103 (4):293-296, October 2008.

Other versions of this document in Nature Precedings

None.

Other versions of this document elsewhere on the web

None known.

Submit a new version link