4 votes

Extracting Functional Modules from Biological Pathways

Sihai D. Zhao¹ and Yong Li¹

Correspondence: (Login to view email address)

1. Molecular Discovery Informatics, GlaxoSmithKline R&D, 709 Swedeland Road, UMW2230, King of Prussia, PA 19406

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Document Type:

Manuscript

Date:

Received 22 December 2007 22:39 UTC; Posted 27 December 2007

Subjects:

Biotechnology, Genetics & Genomics, Bioinformatics

Tags:

• biological pathways
• Functional modules

Abstract:

It has been proposed that functional modules are the fundamental units of cellular function. Methods to identify these modules have thus far relied on gene expression data or protein-protein interaction (PPI) data, but have a few limitations. We propose a new method, using biological pathway data to identify functional modules, that can potentially overcome these limitations. We also construct a network of these modules using functionally relevant PPI data. This network displays the flow and integration of information between modules and can be used to map cellular function.

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License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Zhao, Sihai and Li, Yong. Extracting Functional Modules from Biological Pathways. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2007.1457.1> (2007)

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