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Application of the Sensory Contact Model for Pharmacological Studies under Simulated Clinical Conditions

Natalia N. Kudryavtseva¹, Damira F. Avgustinovich¹, Natalia P. Bondar¹, Michael V. Tenditnik¹ & Irina L. Kovalenko¹

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1. Institute of Cytology and Genetics SD RAS

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Document Type:

Manuscript

Date:

Received 19 December 2007 07:27 UTC; Posted 19 December 2007

Subjects:

Neuroscience, Pharmacology

Tags:

• behavioral study
• sensory contact model
• Pharmacology
• drugs
• psychopathology
• antidepressants

Abstract:

The sensory contact model allows forming different psycho-pathological states (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, addictive states etc.) produced by repeated agonistic interactions in male mice and investigating the therapeutic and preventive properties of any drug as well as its efficiency under simulated clinical conditions. This approach can be useful for a better understanding of the drugs’ action in different stages of disease development in individuals. It is suggested that this behavioral approach and pharmacological designs may be applied for the screening of novel psychotropic drugs.

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License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Kudryavtseva, Natalia, Avgustinovich, Damira, Bondar, Natalia, Tenditnik, Michael, and Kovalenko, Irina. Application of the Sensory Contact Model for Pharmacological Studies under Simulated Clinical Conditions. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2007.1439.1> (2007)

Version info:

Published version:

http://www.ncbi.nlm.nih.gov/pubmed/18473754 (Peer Reviewed) Published as: "An experimental approach for the study of psychotropic drug effects under simulated clinical conditions" in Current Drug Metabolism V.9, N 4, May 2008 p. 352-36

Other versions of this document in Nature Precedings

None.

Other versions of this document elsewhere on the web

• http://arxiv.org/abs/0707.3671 :

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