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Phytochemical Approach and Bioanalytical Strategy to Develop Chaperone-Based Medications

Bernd B. K. Kastenholz¹

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1. Research Centre Juelich, Institute Phytosphere (ICG-3), Germany

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Document Type:

Manuscript

Date:

Received 16 December 2007 18:20 UTC; Posted 18 December 2007

Subjects:

Biotechnology, Chemistry, Neuroscience, Pharmacology

Tags:

• Misfolding diseases
• Metal cofactor
• medicinal plant extracts
• Alzheimer's
• Phytochaperone
• Interactomics

Abstract:

Currently, no pharmaceuticals for the etiological treatment of degenerative protein-misfolding diseases (e.g., ALS, Alzheimer’s or prion diseases) are commercially available. Therefore, in this technical note theoretical considerations and practical approaches concerning the development of chaperone-based medications from medicinal plants (e.g., Ginkgo biloba) are reviewed and discussed in detail. Phytochaperones and other agents isolated from medicinal plants are proposed to serve as the general basis of drug development in protein-misfolding diseases.

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License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Kastenholz, Bernd. Phytochemical Approach and Bioanalytical Strategy to Develop Chaperone-Based Medications. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2007.1431.1> (2007)

Version info:

Other versions of this document in Nature Precedings

Version number	Document title	Date
v2	Posted 09 April 2008

Other versions of this document elsewhere on the web

• 10.2174/1874091X00802010044 (Peer Reviewed): The Open Biochemistry Journal (2008), 2, 44-48

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