Estimation of DNA Sequence Context-dependent Mutation Rates Using Primate Genomic Sequences: Application to Estimation of Selection Bias in Protein (Human TP53) Evolution
Correspondence: (Login to view email address)
- Department of Microbiology & Molecular Genetics, The University of Vermont
- Document Type:
- Presentation
- Date:
- Received 19 October 2007 18:28 UTC; Posted 23 October 2007
- Subjects:
- Ecology, Bioinformatics, Evolutionary Biology
- Abstract:
Understanding of the mechanism of DNA mutation process is critical for studying the functional consequences of genetic variation in clinical medicine (eg. drug response) as well as other complex traits (eg. gene expression and cause of common diseases). During the last several decades, many probabilistic models of DNA nucleotide substitution have been proposed for studying this process. A common feature of these mutation models is that they assume the nucleotides evolve independently at each site. In other words, they are sequence context-independent models. However, based on various biochemical studies, it is now recognized that the DNA mutation process resulting in substitutions in both coding and non-coding regions may depend on sequence context. We proposed here a more realistic sequence context-dependent mutation model, which could contribute to the better understanding of the DNA mutation spectrum in genomes.We also showed its application to protein evolution by separating the mutation bias and selection bias in amino acid substitutions.
- Presented at:
- The Evolution Conference, Fort Collins, CO, 26 June 2004
Discussion
- Votes:
-
0 votes
- Comments:
-
0 comments
- (Login to share with a colleague)
Additional information
- License:
- This document is licensed to the public under the Creative Commons Attribution 2.5 License
- How to cite this document:
-
Zhang, Wei. Estimation of DNA Sequence Context-dependent Mutation Rates Using Primate Genomic Sequences: Application to Estimation of Selection Bias in Protein (Human TP53) Evolution. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2007.1243.1> (2007)
- Version info:
-
Other versions of this document in Nature Precedings
None.
Other versions of this document elsewhere on the web
None known.
