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Activation of TRF3 Transcription Factor by Small Interfering RNAs

Stephan Persengiev¹

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1. Department of Cell Biology and Genetics, Erasmus MC

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Document Type:

Manuscript

Date:

Received 04 October 2007 06:58 UTC; Posted 04 October 2007

Subjects:

Molecular Cell Biology

Tags:

• gene expression
• RNAi
• signaling
• transcription
• siRNA

Abstract:

RNA interference (RNAi) is a conserved biological response to double-stranded RNAs that results in posttranscriptional silencing of target gene expression. Double-stranded processed RNAs of 21-23 nt were found to affect in a non-specific manner a number of signaling and transcription pathways, including interferon and PKR cascades. We report here that siRNAs induce the expression of general transcription factor TRF3, which can trigger an interferon response in mammalian cells.

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This document is licensed to the public under the Creative Commons Attribution 2.5 License

How to cite this document:

Persengiev, Stephan. Activation of TRF3 Transcription Factor by Small Interfering RNAs . Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2007.1206.1> (2007)

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