On The Dangers Of Aligning RNA Sequences Using “Conserved” Motifs
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- DEEB, IBLS, University of Glasgow
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- Document Type:
- Manuscript
- Date:
- Received 18 September 2007 09:05 UTC; Posted 18 September 2007
- Subjects:
- Bioinformatics, Evolutionary Biology
- Abstract:
Aligning RNA sequences can be a challenging task. Automatic sequence alignment programs typically align sequences only with respect to primary sequence, and as a result may yield spurious alignments. Incorporating information on RNA secondary structure can improve the alignment, but this must usually be done by hand. One approach to aligning RNA sequences uses “conserved motifs”, however relying on these motifs may lead to gross errors of alignment if, in fact, those motifs are not conserved.
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- This document is licensed to the public under the Creative Commons Attribution 2.5 License
- How to cite this document:
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Page, Roderic. On The Dangers Of Aligning RNA Sequences Using “Conserved” Motifs . Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2007.1029.1> (2007)
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