http://precedings.nature.com/collections/cirge-symposium-2008/ Recently posted documents in Stanford University: CIRGE Symposium May 9, 2008 Nature Publishing Group en Nature Precedings http://precedings.nature.com/images/header_logo.gif http://precedings.nature.com http://dx.doi.org/10.1038/npre.2008.2657.1 Sir Michael Rutter began the symposium with a broad overview of gene-environment interplay.He described the goals of studying such interactions and pointed to the inherent challenges. He concluded by stressing the need for a variety of strategies for research. To watch Sir Rutter’s presentation, please see the Panel 1 Google Video posting. Panel 1 also features welcoming remarks by Dr. Mildred Cho and Professor Hank Greely, both of Stanford University. http://dx.doi.org/10.1038/npre.2008.2657.1 Mon, 15 Dec 2008 20:02:01 UTC Perspectives on Gene-Environment Interplay in Psychiatry doi:10.1038/npre.2008.2657.1 2008-12-15 Michael Rutter Nature Precedings 2008-12-15T20:02:01Z Presentation Genetics & Genomics http://creativecommons.org/licenses/by/3.0/ http://dx.doi.org/10.1038/npre.2008.2656.1 Dr. Kenneth Schaffner gave a brief introduction to the symposium topics. He began with a history of the thinking on gene-environment interactions and described the ensuing controversies. He cited the lack of a consensus theory of the environment and then described some methodological and technological advances in the studies of gene-environment interactions.To watch Dr. Schaffner’s presentation, please see the Panel 1 Google Video posting. http://dx.doi.org/10.1038/npre.2008.2656.1 Mon, 15 Dec 2008 19:58:51 UTC History and Philosophy of Gene Environment Interaction doi:10.1038/npre.2008.2656.1 2008-12-15 Kenneth Schaffner Nature Precedings 2008-12-15T19:58:51Z Presentation Genetics & Genomics http://creativecommons.org/licenses/by/3.0/ http://dx.doi.org/10.1038/npre.2008.2655.1 Dr. Eric Turkheimer focused on the nonshared environment project and pointed to the nonshared environment and its components as the central problem of human scientific psychology. He described three causal models, applying them to each genetic and environmental causation, and concluded that rough measurements lead to detectable causations, but more precise measurements make the effects harder to detect. To watch Dr. Turkheimer’s presentation, please see the Panel 2 Google Video posting. http://dx.doi.org/10.1038/npre.2008.2655.1 Mon, 15 Dec 2008 19:15:53 UTC The Costs and Benefits of Lousy Measures of the Environment doi:10.1038/npre.2008.2655.1 2008-12-15 Eric Turkheimer Nature Precedings 2008-12-15T19:15:53Z Presentation Genetics & Genomics http://creativecommons.org/licenses/by/3.0/ http://dx.doi.org/10.1038/npre.2008.2654.1 Dr. Andrew Perrin discussed the ontological claims and social theory which run beneath ideas of genetic causation of behavioral traits. He outlined five criteria for evaluating and conceptualizing the environment within genetic studies. He concluded by emphasizing complexity and describing gene-environment interaction chains.To watch Dr. Perrin’s presentation, please see the Panel 2 “Google Video posting.”:http://video.google.com/videoplay?docid=-8804321603731619003&hl=en http://dx.doi.org/10.1038/npre.2008.2654.1 Mon, 15 Dec 2008 18:39:13 UTC The Undertheorized Environment: Sociological Insights for Behavioral Genetics doi:10.1038/npre.2008.2654.1 2008-12-15 Andrew Perrin Nature Precedings 2008-12-15T18:39:13Z Presentation Genetics & Genomics http://creativecommons.org/licenses/by/3.0/ http://dx.doi.org/10.1038/npre.2008.2653.1 Dr. Ruth Ottman first discussed different models of gene-environment interactions and then delved into designs of studies attempting to elucidate such interactions. She stressed the importance of using the correct measurement scale, whether additive or multiplicative, noting that the additive measurement scale is more consistent with biological models. Dr. Ottman concluded by reminding the audience of the need for very large sample sizes, and thus collaboration, in gene-environment interaction studies. To watch Dr. Ottman’s presentation, please see the Panel 2 Google Video posting. http://dx.doi.org/10.1038/npre.2008.2653.1 Mon, 15 Dec 2008 18:26:42 UTC Gene-Environment Interaction: Definitions and Study Designs doi:10.1038/npre.2008.2653.1 2008-12-15 Ruth Ottman Nature Precedings 2008-12-15T18:26:42Z Presentation Genetics & Genomics http://creativecommons.org/licenses/by/3.0/ http://dx.doi.org/10.1038/npre.2008.2652.1 Dr. David Craig began by explaining expression and linkage studies. He then focused on genome-wide association studies (GWAS), giving examples from Diabetes Type 2 and Alzheimer’s research. Dr. Craig concluded with the recognition that GWAS cannot at the present adequately account for environmental influences on disease.To watch Dr. Craig’s presentation, please see the Panel 3 Google Video posting. http://dx.doi.org/10.1038/npre.2008.2652.1 Mon, 15 Dec 2008 18:25:15 UTC Identification of Common Genetic Variants Predisposing to Neurobehavioral Disease by way of Genome-Wide SNP Association Studies doi:10.1038/npre.2008.2652.1 2008-12-15 David Craig Nature Precedings 2008-12-15T18:25:15Z Presentation Genetics & Genomics http://creativecommons.org/licenses/by/3.0/ http://dx.doi.org/10.1038/npre.2008.2651.1 Dr. Catherine Schaefer described Kaiser Permanente’s Research Program on Genes, Environment and Health, which will be a large resource facilitating further studies analyzing the influence of genes and the environment. She described both the goals and the processes of the program in detail.To watch Dr. Schaefer’s presentation, please see the Panel 3 Google Video posting. Panel 3 also features a presentation by Dr. Atul Butte of Stanford University on “Linking the Genome and Envirome.” http://dx.doi.org/10.1038/npre.2008.2651.1 Mon, 15 Dec 2008 18:02:10 UTC The Physical and Social Environment in Kaiser Permanente’s Research Program in Genes, Environment and Health doi:10.1038/npre.2008.2651.1 2008-12-15 Catherine Schaefer Nature Precedings 2008-12-15T18:02:10Z Presentation Genetics & Genomics http://creativecommons.org/licenses/by/3.0/ http://dx.doi.org/10.1038/npre.2008.2650.1 Dr. Paul Wise began with a brief overview of policy formation, specifically that related to child development. He then delved into the changing taxonomy of disease and its implications for policy. He concluded by stressing the need for frameworks for collective action to reframe policy in terms of gene-environment interactions.To watch Dr. Wise’s presentation, please see the Panel 4 Google Video posting. Panel 4 also features presentations by Dr. Richard Sharp of the Cleveland Clinic on “Disease Advocacy and Contested Environments” and by Professor Sara Shostak of Brandeis University on “Sealing Complexity: Genetics, Social Structure and Policy Environments.” To view more of the Capturing Complexity Symposium, please see the Panel 5 Google Video posting, featuring Drs. Marc Feldman and Paul Ehrlich of Stanford University and Sir Michael Rutter of the Institute of Psychiatry, London. Dr. Feldman explored the lack of consideration of environmental influences in recent genome-wide association studies. Dr. Ehrlich also stressed the importance of the environment, and Sir Rutter concluded by responding to evocative topics brought up earlier in the Symposium such as personalized insurance policies, causation models and translational research.To view the final deliberative discussion, involving all panelists and moderated by Professor Hank Greely, JD, please see the Panel 6 Google Video posting. http://dx.doi.org/10.1038/npre.2008.2650.1 Mon, 15 Dec 2008 17:05:44 UTC The Policy Requirements of Gene-Environment Research doi:10.1038/npre.2008.2650.1 2008-12-15 Paul Wise Nature Precedings 2008-12-15T17:05:44Z Presentation Genetics & Genomics http://creativecommons.org/licenses/by/3.0/